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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis

Fig. 2

PLXNC1 alters expression of hallmark inflammasome proteins after CLP. Levels of A IL-1ß B IL-18 and C caspase-11 in the peritoneal lavage of PLXNC1-/- animals and littermate controls. Western blot analysis of D caspase-1, E caspase-11, F gasdermin D, and G NLRP3 in PLXNC1-/- animals during sepsis. (Asterisks mark the proform of caspase-1, caspase-11, and GSDMD, respectively. Arrows point at the cleaved p20 and p10 fragments of caspase-1 and caspase-11, respectively, cleaved GSDMD at around 31 kDa and 22 kDa, and full form of NLRP3.) H Phospho Explorer Antibody Array 24 h after CLP in PLXNC1-/- mice and littermate controls during CLP induced sepsis. (The data are presented as the means ± SEMs; n = 5–11 mice/group; Western blots, n = 3 mice/group; *p < 0.05; **p < 0.01 and ***p < 0.001 as indicated. The illustration for Fig. 2H has been created using biorender.com.) ADCY4, Adenylate cyclase 4; AKAP, A-kinase anchoring protein; AMP, adenosine monophosphate; ATF2/4, Activating transcription factor 2/2; ATP, adenosine triophosphate; BRAF, B-rapidly accelerated fibrosarcoma; cAMP, cyclic adenosine monophosphate; cAMP-Gef, cAMP-activated guanine nucleotide exchange factor; Calm1, Camodulin-1; CAMK1/2A/2B/4, Calcium/Calmodulin-dependent protein kinase type 1/2A/2B/4; CNG, cyclic nucleotide-gated channel; DUSP1, Dual specificity phosphatase 1; ERK1/2, Extracellular signal-regulated kinase 1/2; GRK2, G-protein coupled receptor 2; ICER, Inducible cAMP early repressor; MAP2K1/2, Mitogen-activated kinase kinase 1/2; OPRM1, Opioid receptor Mu 1; PKAcs, Protein kinase A catalytic subunit; PDE, phosphodiesterase; PKAr, Protein kinase A regulatory subunit; PKI, Protein kinase inhibitor peptide; PRKACA, Protein kinase cAMP-activated catalytic subunit alpha; PRKAR2B, cAMP-dependent protein kinase type-II-beta regulatory subunit; RAF1, Rapidly accelerated fibrosarcoma-1; RAP1A, Ras-related protein 1A; RPS6KA1, Ribosomal protein S6 kinase alpha-1; SRC, Tyrosine protein kinase Src; STAT3, Signal transducers and activators of transcription

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Journal of Biomedical Science

ISSN: 1423-0127