Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Figure 4 | Journal of Biomedical Science

Figure 4

From: Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine

Figure 4

Antinociceptive response in prenatally saline-exposed male rats after acute or the third (or second) injection of different opioids. Rats received an acute injection of morphine (10 mg/kg), methadone (5 mg/kg), or buprenorphine (1.5 mg/kg), s.c., at age 8-12 weeks. (A) The latency and the AUC of the first morphine, methadone, or buprenorphine injection. (B) The latency and the AUC of the 3rd morphine and methadone or the 2nd buprenorphine injection. (C) Rate of tolerance development to different opioids in prenatally saline-exposed rats. The rate of tolerance development showed a steeper slope in the buprenorphine-treated group than that of the morphine- or methadone-treated group. All data are expressed as mean ± S.E.M, (N = 4 in methadone and buprenorphine treatment group; N = 19 in morphine treatment group), *p < 0.05, ***p < 0.001 compared to buprenorphine group.

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127