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  1. Gemcitabine (GEM) is used as a first-line therapy for patients diagnosed with any stage of pancreatic cancer (PC); however, patient survival is poor because of GEM resistance. Thus, new approaches to overcome ...

    Authors: Eun-Jeong Jeong, Yuna Roh, Eunsun Jung, Jin-Seong Hwang, Taesang Son, Hyun Seung Ban, Tae-Su Han, Young-Kug Choo and Jang-Seong Kim
    Citation: Journal of Biomedical Science 2025 32:49
    Content type: Research Published on:

  2. Asthma is a chronic inflammatory lung disease driven by a complex interplay between innate and adaptive immune components. Among these, innate lymphoid cells (ILCs) and innate-like lymphocytes have emerged as ...

    Authors: Christina Li-Ping Thio, Jheng-Syuan Shao, Chia-Hui Luo and Ya-Jen Chang
    Citation: Journal of Biomedical Science 2025 32:48
    Content type: Review Published on:

  3. Skin barrier dysfunction and immune activation are hallmarks of inflammatory skin diseases such as rosacea and psoriasis, suggesting shared pathogenic mechanisms. While barrier disruption may trigger or exacer...

    Authors: Mengting Chen, Yaling Wang, Mei Wang, San Xu, Zixin Tan, Yisheng Cai, Xin Xiao, Ben Wang, Zhili Deng and Ji Li
    Citation: Journal of Biomedical Science 2025 32:47
    Content type: Research Published on:

  5. The emergence of Artificial Intelligence (AI), particularly Chat Generative Pre-Trained Transformer (ChatGPT), a Large Language Model (LLM), in healthcare promises to reshape patient care, clinical decision-ma...

    Authors: Usman Iqbal, Afifa Tanweer, Annisa Ristya Rahmanti, David Greenfield, Leon Tsung-Ju Lee and Yu-Chuan Jack Li
    Citation: Journal of Biomedical Science 2025 32:45
    Content type: Research Published on:

  6. The evolution of SARS-CoV-2, particularly through new variants, presents significant global health challenges due to their potential for immune evasion and reduced vaccine effectiveness. This study aims to inv...

    Authors: Che-Mai Chang, Chang-Jiun Wu, Maxim Shkurnikov, Chin-Lin Guo, Wan-Chen Huang, Alexander Tonevitsky and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2025 32:44
    Content type: Research Published on:

  7. Anxiety is an innate response in the face of danger. When anxiety is overwhelming or persistent, it could be considered an anxiety disorder. Recent studies have shown that acid-sensing ion channels (ASICs) rep...

    Authors: Ya-Chih Chien, Shing-Hong Lin, Cheng-Chang Lien, John N. Wood and Chih-Cheng Chen
    Citation: Journal of Biomedical Science 2025 32:43
    Content type: Research Published on:

  8. Authors: Qiuming Zeng, Hui Guo, Na Tang, Pranav S. Renavikar, Nitin J. Karandikar, Amy E. Lovett-Racke, Michael K. Racke, Chengkai Yan, Rong Tang, Sushmita Sinha, Krishnendu Ghosh, Jeremy P. Ryal, Song Ouyang, Min Chen, Foued Amari, Coppola Vincenzo…
    Citation: Journal of Biomedical Science 2025 32:42
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2025 32:26

  10. Mutations in the HERG potassium channel are a major cause of long QT syndrome type 2 (LQT2), which can lead to sudden cardiac death. The HERG channel plays a critical role in the repolarization of the myocardi...

    Authors: Amit Kumawat, Elisa Tavazzani, Giovanni Lentini, Alessandro Trancuccio, Deni Kukavica, Amanda Oldani, Marco Denegri, Silvia G. Priori and Carlo Camilloni
    Citation: Journal of Biomedical Science 2025 32:40
    Content type: Research Published on:

  11. Phosphorylation and O-GlcNAcylation are the key modifications regulating RNA Polymerase II (RNA Pol II)-driven transcription. Transcriptional kinases, cyclin-dependent kinase 7 (CDK7), CDK9 and CDK12 phosphory...

    Authors: Aishwarya Gondane and Harri M. Itkonen
    Citation: Journal of Biomedical Science 2025 32:39
    Content type: Research Published on:

  12. Endolysins are promising alternatives to antibiotics because they can lyse bacterial cells rapidly with a low risk of resistance development, however, their effectiveness against Gram-negative bacteria is hind...

    Authors: Joonbeom Kim, Su Min Son, Eunbyeol Ahn, Haejoon Park and Sangryeol Ryu
    Citation: Journal of Biomedical Science 2025 32:38
    Content type: Research Published on:

  13. Social interaction is crucial for mental health across animal species. Social experiences, especially in early-life stages, strongly influence brain function and social behavior later in life. Acute social iso...

    Authors: Hsin-Tzu Chang, Kuan-Hsiang Cheng, Yu-Chieh Hung and Kuei-Sen Hsu
    Citation: Journal of Biomedical Science 2025 32:37
    Content type: Research Published on:

  14. Triple-negative breast cancer (TNBC) is characterized by high malignancy, strong invasiveness, and a propensity for distant metastasis, leading to poor prognosis and relatively limited treatment options. Metfo...

    Authors: Zhangyuan Gu, Fugui Ye, Hong Luo, Xiaoguang Li, Yue Gong, Shiqi Mao, Xiaoqing Jia, Xiangchen Han, Boyue Han, Yun Fu, Xiaolin Cheng, Jiejing Li, Zhiming Shao, Peizhen Wen, Xin Hu and Zhigang Zhuang
    Citation: Journal of Biomedical Science 2025 32:36
    Content type: Research Published on:

  15. Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established. Here, we invest...

    Authors: Nasrin Mortazavi, Puneet Talwar, Ekaterina Koshmanova, Roya Sharifpour, Elise Beckers, Alexandre Berger, Islay Campbell, Ilenia Paparella, Fermin Balda, Ismael Dardour Hamzaoui, Christian Berthomier, Christine Bastin, Christophe Phillips, Pierre Maquet, Fabienne Collette, Mikhail Zubkov…
    Citation: Journal of Biomedical Science 2025 32:35
    Content type: Research Published on:

  16. Glioblastoma multiforme (GBM) is an aggressive brain tumor with chemoresistant, immunosuppressive, and invasive properties. Despite standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) c...

    Authors: Gilbert Aaron Lee, Justin Bo-Kai Hsu, Yu-Wei Chang, Li-Chun Hsieh, Yi-Tien Li, Ying Chieh Wu, Cheng-Ying Chu, Yung-Hsiao Chiang, Wan-Yuo Guo, Chih-Chun Wu, Liang-Wei Chen, Hung-Wen Kao, Wan-Li Lin, Li‑Wen Tseng, Ting-Wei Weng, Duen-Pang Kuo…
    Citation: Journal of Biomedical Science 2025 32:34
    Content type: Research Published on:

  18. Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant l...

    Authors: Ying Fang, Yuning Chen, Siyue Niu, Zibai Lyu, Yanxin Tian, Xinyuan Shen, Yan-Ruide Li and Lili Yang
    Citation: Journal of Biomedical Science 2025 32:32
    Content type: Review Published on:

  19. Adipose tissue plays a pivotal role in systemic metabolism and maintaining bodily homeostasis. Exosomes from adipose tissues, known as AT-Exos, are recognized as important messengers in the communication betwe...

    Authors: Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang and Li-wei Dong
    Citation: Journal of Biomedical Science 2025 32:31
    Content type: Research Published on:

  21. Tumor metastasis is responsible for approximately 90% of mortality in lung cancer. Understanding the molecular mechanisms of lung cancer metastasis is crucial for developing new treatment strategies. Cellular ...

    Authors: Hsiang-Ling Ho, Shin-Chih Lin, Chao-Wei Chiang, Ching Lin, Che-Wei Liu, Yi-Chen Yeh, Mei-Yu Chen and Teh-Ying Chou
    Citation: Journal of Biomedical Science 2025 32:28
    Content type: Research Published on:

  22. The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats f...

    Authors: Ren-Jye Lin, Li-Hsiung Lin, Zih-Ping Chen, Bing-Cheng Liu, Pin-Chen Ko and Ching-Len Liao
    Citation: Journal of Biomedical Science 2025 32:27
    Content type: Research Published on:

  23. The largest dengue virus 2 (DENV2) outbreak occurred in Taiwan in 2015, resulting in many fatalities. We therefore aim to identify crucial genetic variations which determine the virulence of the 2015 Taiwan ou...

    Authors: Jing-Ru Hee, Dayna Cheng, Yu-Hong Chen, Sheng-Hsuan Wang, Chiao-Hsuan Chao, Sheng-Wen Huang, Pin Ling, Shu-Wen Wan, Chih-Peng Chang, Justin Jang Hann Chu, Trai-Ming Yeh and Jen-Ren Wang
    Citation: Journal of Biomedical Science 2025 32:25
    Content type: Research Published on:

  24. The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown. Th17 cells are believed to play a pivo...

    Authors: Qiuming Zeng, Hui Guo, Na Tang, Pranav S. Renavikar, Nitin J. Karandikar, Amy E. Lovett-Racke, Michael K. Racke, Chengkai Yan, Rong Tang, Sushmita Sinha, Krishnendu Ghosh, Jeremy P. Ryal, Song Ouyang, Min Chen, Foued Amari, Coppola Vincenzo…
    Citation: Journal of Biomedical Science 2025 32:26
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2025 32:42

  25. The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cells, bone cells, blood and immune cells, heart cells, glia and stem neural cells. It belo...

    Authors: Claudia Tito, Silvia Masciarelli, Gianni Colotti and Francesco Fazi
    Citation: Journal of Biomedical Science 2025 32:24
    Content type: Review Published on:

  26. Recent advancements have revealed the presence of a microbiome within tumor tissues, underscoring the crucial role of the tumor microbiome in the tumor ecosystem. This review delves into the characteristics of...

    Authors: Na Wang, Si Wu, Lanxiang Huang, Yue Hu, Xin He, Jourong He, Ben Hu, Yaqi Xu, Yuan Rong, Chunhui Yuan, Xiantao Zeng and Fubing Wang
    Citation: Journal of Biomedical Science 2025 32:23
    Content type: Review Published on:

  27. Skeletal muscle atrophy involves significant remodeling of fibers and is characterized by deficits in mitochondrial content and function. These changes are intimately connected to shifts in mitochondrial turno...

    Authors: Fasih A. Rahman, Mackenzie Q. Graham, Amanda M. Adam, Emma S. Juracic, A. Russell Tupling and Joe Quadrilatero
    Citation: Journal of Biomedical Science 2025 32:29
    Content type: Research Published on:

  28. This study aimed to investigate the population heterogeneity on carbapenem susceptibility in Klebsiella pneumoniae strains that acquired a blaOXA-232-bearing ColE-type plasmid.

    Authors: Yun Young Cho, Sun Ju Kim and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2025 32:22
    Content type: Research Published on:

  29. Reactive oxygen species (ROS) are increased in diabetic conditions and play a causal role in diabetic foot ulcers (DFU). We previously showed that ROS up-regulate miR-200c expression, that in turns causes apop...

    Authors: Marco D’Agostino, Sara Sileno, Daniela Lulli, Naomi De Luca, Claudia Scarponi, Massimo Teson, Alessio Torcinaro, Francesca De Santa, Corrado Cirielli, Sergio Furgiuele, Chris H. Morrell, Elena Dellambra, Teresa Odorisio, Edward G. Lakatta, Daniele Avitabile, M. C. Capogrossi…
    Citation: Journal of Biomedical Science 2025 32:21
    Content type: Research Published on:

  30. Diabetic neuropathy (DN) is a prevalent and painful complication of diabetes; however, the mechanisms underlying its pathogenesis remain unclear, and effective clinical treatments are lacking. This study aims ...

    Authors: Yu Mei Yang, Hang Bin Ma, Yue Xiong, Qian Wu and Xiu Kui Gao
    Citation: Journal of Biomedical Science 2025 32:20
    Content type: Research Published on:

  31. The application of biomimetic and stimuli-responsive nanocarriers displays considerable promise in improving the management of bacterial sepsis and overcoming antimicrobial resistance. Therefore, the study aim...

    Authors: Eman Elhassan, Calvin A. Omolo, Mohammed A. Gafar, Eman A. Ismail, Usri H. Ibrahim, Rene Khan, Mathieu Lesouhaitier, Paul Kubes and Thirumala Govender
    Citation: Journal of Biomedical Science 2025 32:19
    Content type: Research Published on:

  34. Artificial intelligence (AI) has emerged as a transformative force in precision medicine, revolutionizing the integration and analysis of health records, genetics, and immunology data. This comprehensive revie...

    Authors: Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin and Yang C. Fann
    Citation: Journal of Biomedical Science 2025 32:16
    Content type: Review Published on:

  35. The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. The limited number of established targets furthe...

    Authors: Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia and Kyeong Kyu Kim
    Citation: Journal of Biomedical Science 2025 32:15
    Content type: Research Published on:

  36. The deployment of Artificial Intelligence (AI) in healthcare has the potential to transform patient care through improved diagnostics, personalized treatment plans, and more efficient resource management. Howe...

    Authors: Rodrigo R. Gameiro, Naira Link Woite, Christopher M. Sauer, Sicheng Hao, Chrystinne Oliveira Fernandes, Anna E. Premo, Alice Rangel Teixeira, Isabelle Resli, An-Kwok Ian Wong and Leo Anthony Celi
    Citation: Journal of Biomedical Science 2025 32:14
    Content type: Research Published on:

  37. Malaria parasites establish new permeation pathways (NPPs) at the red blood cell membrane to facilitate the transport of essential nutrients from the blood plasma into the infected host cell. The NPPs are crit...

    Authors: Mitchell L. Trickey, Mrittika Chowdury, Georgina Bramwell, Natalie A. Counihan and Tania F. de Koning-Ward
    Citation: Journal of Biomedical Science 2025 32:13
    Content type: Research Published on:

  38. Deficient DNA repair and excessive DNA damage contribute to neurodegenerative disease. However, the role of DNA damage and repair in spinal cord injury (SCI) is unclear. SCI, a debilitating disruption of the s...

    Authors: Elle EM Scheijen, Naomi Veeningen, Sam Duwé, Anna Ivanova, Jana Van Broeckhoven, Sven Hendrix and David M Wilson III
    Citation: Journal of Biomedical Science 2025 32:12
    Content type: Research Published on:

  39. Chronic hepatitis B virus (HBV) infection is a major risk for development of hepatocellular carcinoma (HCC), a frequent malignancy with a poor survival rate. HBV infection results in significant endoplasmic re...

    Authors: Alina-Veronica Ghionescu, Mihaela Uta, Andrei Sorop, Catalin Lazar, Petruta R. Flintoaca-Alexandru, Gabriela Chiritoiu, Livia Sima, Stefana-Maria Petrescu, Simona Olimpia Dima and Norica Branza-Nichita
    Citation: Journal of Biomedical Science 2025 32:11
    Content type: Research Published on:

  40. Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to the COVID-19 pandemic. The widespread administration of mRNA vaccines agains...

    Authors: Hung-Chun Liao and Shih-Jen Liu
    Citation: Journal of Biomedical Science 2025 32:10
    Content type: Review Published on:

  41. Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond glycolysis in the pathophysiology of multiple myeloma (MM) remains largely elusive. Herein, this...

    Authors: Xuejie Gao, Qilin Feng, Qikai Zhang, Yifei Zhang, Chaolu Hu, Li Zhang, Hui Zhang, Guanli Wang, Ke Hu, Mengmeng Ma, Zhuning Wang, Yujie Liu, Dong An, Hongfei Yi, Yu Peng, Xiaosong Wu…
    Citation: Journal of Biomedical Science 2025 32:9
    Content type: Research Published on:

  42. Recent studies indicate that N6-methyladenosine (m6A) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation.

    Authors: Haisheng Zhang, Cheng Yi, Jianing Li, Yunqing Lu, Haoran Wang, Lijun Tao, Jiawang Zhou, Yonghuang Tan, Jiexin Li, Zhuojia Chen, Gholamreza Asadikaram, Jie Cao, Jianxin Peng, Wanglin Li, Junming He and Hongsheng Wang
    Citation: Journal of Biomedical Science 2025 32:8
    Content type: Research Published on:

  43. Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironme...

    Authors: Zhipeng Cao, Sadia Quazi, Sakshi Arora, Laura D. Osellame, Ingrid J. Burvenich, Peter W. Janes and Andrew M. Scott
    Citation: Journal of Biomedical Science 2025 32:7
    Content type: Review Published on:

  44. Obesity is becoming one of the major non-communicable diseases with increasing incidence and risks that cannot be ignored. However effective and safe clinical treatment strategies still need to be deeply explo...

    Authors: Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li and Robert Chunhua Zhao
    Citation: Journal of Biomedical Science 2025 32:6
    Content type: Research Published on:

  45. The association between the intestinal microbiota and colorectal cancer (CRC) has been extensively studied, with Fusobacterium nucleatum (F. nucleatum, FN) being found in high abundance in colorectal cancer tissu...

    Authors: Yulong Yu, Han Yin, Bili Wu, Weiheng Zhao, Yuan Wang, Aifeina Aili, Mu Yang, Qianqian Yu and Xianglin Yuan
    Citation: Journal of Biomedical Science 2025 32:5
    Content type: Research Published on:

  46. Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and the potential risk of emerging global outbreaks. Flavivirus disease pathog...

    Authors: Pedro Pablo Martínez-Rojas, Verónica Monroy-Martínez and Blanca H. Ruiz-Ordaz
    Citation: Journal of Biomedical Science 2025 32:4
    Content type: Review Published on:

  47. The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, ...

    Authors: Raluca E. Ghebosu, Lawrence Hui and Joy Wolfram
    Citation: Journal of Biomedical Science 2025 32:3
    Content type: Review Published on:

  48. In regions with a high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, coinfected patients face a heightened risk of developing hepatocellular carcinoma (HCC), termed HBV/...

    Authors: Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Rey-Heng Hu, Sheng-Tai Tzeng, Ya-Chun Wang, Yasuhito Tanaka, Pei-Jer Chen and Shiou-Hwei Yeh
    Citation: Journal of Biomedical Science 2025 32:2
    Content type: Research Published on:

  49. ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading ...

    Authors: Jing Wang, Chunshuang Li, Jinling Han, Yaoyao Xue, Xu Zheng, Ruoxi Wang, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh and Xueqing Ba
    Citation: Journal of Biomedical Science 2025 32:1
    Content type: Review Published on:

  50. The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlying mechanism and causative factors, with the hope of developing novel therapeutic strate...

    Authors: Aviral Kumar, Kenneth Chun-Hong Yap, Bandari BharathwajChetty, Juncheng Lyu, Mangala Hegde, Mohamed Abbas, Mohammed S. Alqahtani, Soham Khadlikar, Ali Zarrabi, Arezoo Khosravi, Alan Prem Kumar and Ajaikumar B. Kunnumakkara
    Citation: Journal of Biomedical Science 2024 31:105
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127