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Table 1 Effects of prenatal exposure to opioids on offspring

From: Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine

 

Saline

Morphine

Methadone

Buprenorphine

  

Mean ± SEM

 

Number of offspring per litter

10.9 ± 0.2

10.5 ± 0.3

9.8 ± 0.3

10.2 ± 0.3

Fatality (%)

0.69 ± 0.33

0

0

7.1 ± 2.38**

Fatality occurred in the offspring (%) (P2-P10)

0.21 ± 0.14

0

0.56 ± 0.56

12.14 ± 7.02*

Body weight increase in the dams (g) (E3-E20)

148.1 ± 2.7

132.3 ± 4.2**

121.3 ± 3.3***

136.4 ± 3.7*

Body weight of the offspring at birth (g)

6.8 ± 0.1

7 ± 0.1

6.6 ± 0.1

6.9 ± 0.1

Body weight of the offspring on day 7 (g)

14.7 ± 0.3

16.3 ± 0.5*

14.5 ± 0.4

13.5 ± 0.4*

  1. *Significantly different compared to saline group, p < 0.05
  2. **Significantly different compared to saline group, p < 0.01
  3. ***Significantly different compared to saline group, p < 0.001
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Journal of Biomedical Science

ISSN: 1423-0127