Skip to main content
Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling

Fig. 7

Model for POSTN modulated ovarian cancer malignancy. The diagram illustrates POSTN-mediated signaling axis to induce ERK-p38 and IKKβ-mediated NF-κB activation. This leads to cytokines/chemokines production, as well as monocyte mobilization and differentiation to enrich M2 macrophages and also induces TGF-β2 expression to activate CAFs in the tumor microenvironment

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127