Fig. 4

Proteomic changes related to cell administration. A Graphical representation of the main enriched functions found up- or down-regulated in cell treated mice (AT and CB vs. IC untreated ones (n:8 biological replicates, BR, per group), based on the information provided by IPA (-log p-value). B Ingenuity (IPA) functional network with proteins up- (red) or down-regulated (green) correlating with several functions altered in response to ischemia and modulated after cell administration (AT and CB vs IC, n:8 BR per group). C Representative graphs of some of the differential expression patterns most frequently seen (Log2 LFQ intensities), with the name of some proteins that follow such patterns (BR: SH, IC, AT, CB, n:8 per group). From D to H Box and plots graphs representing the median, min and max values (with all points registered) of the label-free quantification (LFQ) intensities (Log2) registered for several proteins with differential expression in AT or CB mice vs IC untreated ones, as well as the receiver operating characteristic (ROC) analysis registered for these proteins, indicating the area under curve (AUC) and respective p-values (BR: SH, IC, AT, CB, n:8 per group). Differences were considered significant when p-values < 0.05. *p-value < 0.05, *p-value < 0.01, *p-value < 0.001 after performing Kruskal Wallis and Dunn’s test as post-hoc