Fig. 1

Aberrant synaptic transmission and LTP in CPEB2-cKO^Nes SC-CA1 pathway. A Mice carrying the Cpeb2 allele with two loxP sites flanking exons 3–5 (fCPEB2) were crossed with Nestin-Cre mice to generate CPEB2-cWT and -cKO^Nes mice. CPEB2 immunohistochemistry of coronal brain slices was from adult CPEB2-cWT and -cKO^Nes mice. B-D Electrophysiological responses in the SC-CA1 pathway of adult (3- to 5-month-old) mice, including the input–output curve of the fEPSP slope and fiber volley amplitude in response to increasing stimulus intensity (B), paired-pulse facilitation (C), and LTP evoked by 4X HFS (D). Sample traces were the average fEPSP of 5 min before (gray) and the very last 5 min (black) after stimulation. Numbers in parentheses (n/N) represent the number of recorded slices (n) and mice (N). Sample traces with vertical scales of 0.5 mV and horizontal scales of 10 ms (i-o curve and LTP) and 50 ms (PPF). Data are mean ± SEM. *P < 0.05 and **P < 0.01, two-way ANOVA with Fisher’s LSD post-hoc comparison