Fig. 4
Impaired spatial memory consolidation in CPEB2-cKOVglut2 mice. A-E Adult male mice at 2 to 4 months old were used for behavior assays. A Open-field. Representative moving traces in the open arena during the first 10 min and the quantified entry times, duration, moving distance and velocity. B Elevated plus maze (EPM). Representative 5-min moving traces in the EPM and the quantified entry times, duration and moving distance in the open versus closed arms. C Morris water maze (MWM). Mice were trained with 4 trials per day for 4 consecutive days, and the escape latency to the platform was averaged from 4 trials. D The MWM probe test on day 5 recorded the percentage of time (total 60 s) spent in each quadrant. E In the visual MWM task, the velocity and latency reflected the swimming ability and visual acuity, respectively. Data are mean ± SEM. **P < 0.01, Student’s t test and two-way ANOVA with Fisher’s LSD post-hoc test. The number of mice for behavioral assays was denoted in parentheses