Fig. 1

Comparison of CD4+ T-cell profile between both PWH groups with NHC group in relation to A: development and activation and B: senescence. Statistics: The AMR values were obtained using a GAMLSS with beta distribution adjusted by age, sex at birth, and antiretroviral therapy. Only statistically significant results for any of the two comparisons are shown (filled balls, p<0.05 and q<0.15). LLV PWH with low-level viremia (50–200 copies/mL), SV PWH with virologic suppression (<50 copies/mL), NHC non-infected HIV controls, aAMR adjusted arithmetic mean ratio, N naïve T-cells, CM central memory T-cells, EM memory effector T-cells, TEMRA pE1 pre-terminally differentiated effector memory RA+ 1 T-cells, TEMRA pE2 pre-terminally differentiated effector memory RA+ 2 T-cells, TEMRA E terminally differentiated effector memory RA+ T-cells, HAVCR2 also known as TIM3