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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment

Fig. 2

Apt-2cNP demonstrated enhanced cellular internalization and the highest cytotoxicity. Cytotoxicity of 2c, 2cNP, and Apt-2cNP was determined by MTT assay on (A) HT-29 and (B) HCT116 cells. Flow cytometric analysis of the intracellular uptake in (C) HT-29 cells for 2c (1st histogram, sea green), 2cNP (2nd histogram, reddish brown) and Apt-2cNP (3rd histogram, light orange) as well as in (D) HCT116 cells for 2c (1st histogram, Sky blue), 2cNP (2nd histogram, light red) and Apt-2cNP (3rd histogram, light green) at 6 h. Confocal microscopy of (E) HT-29 and (F) HCT116 cells treated with 2cNP and Apt-2cNP for 2 h, 4 h and 6 h (Blue = DAPI, Red = Cy5). Data shows mean ± SD (n = 3). *p < 0.05 was considered as the statistical level of significance

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Journal of Biomedical Science

ISSN: 1423-0127