Fig. 1
From: Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
PLXNC1 reduces sepsis mortality and suppresses inflammatory damage in vivo. A model of midgrade polymicrobial sepsis using caecal ligation and puncture (CLP) was established in mice. A Survival curves of PLXNC1-/- mice and their littermate controls over the course of 96 h. Levels of B TNF-α, C IL-6 and D KC measured by ELISA in the peritoneal lavage fluid of PLXNC1-/- mice 24 h after CLP induction. E Histological analysis of liver tissue sections and F evaluation of liver damage by the Suzuki score (yellow arrows pointing at vacuolation and congestion of hepatocytes). G Serum levels of AST. H Histological analysis of colon sections (arrows pointing at epithelial lifting; asterisk marking necrosis), and evaluation of intestinal damage by I Chiu’s score. (The data are presented as the means ± SEMs; n = 5–11 mice/group; histology, n = 3 mice/group; *p < 0.05; **p < 0.01 and ***p < 0.001 as indicated)