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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma

Fig. 7

Overexpression of pGSN suppresses tumor growth by reducing TNC expression and CAF activation in vivo. A Tumor growth of xenografts co-transplanted with CE81T-R (EV or pGSN overexpression) and fibroblasts 3T3 cells. B and C Tumor size (B) and tumor weight (C) were measured at the end of the experiment. D ELISA analysis of circulating pGSN in mice at the end of the experiment. E, mRNA expressions of pGSN, TNC, and CAF markers (ACTA2, LIF, and TAGLN) were determined by RT-qPCR analysis. F IHC staining of pGSN, TNC, αSMA, collagen, CD86 M1 and CD206 M2 macrophage markers in tumors. Data represents mean ± s.e.m. ns: non-significant; *p < 0.05; **p < 0.01; ***p < 0.001

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Journal of Biomedical Science

ISSN: 1423-0127