Table 1 Comprehensive analysis and main characteristics of the thirty-seven selected articles
From: Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
ncRNAs | Samples | ncRNA DE levels | IR dosage (Gy) | Assay(s)—IR effect | Refs. | |
|---|---|---|---|---|---|---|
TNBC | Controls | |||||
miRNAs | ||||||
Let-7d | WT–MDA-MB-231, HS587-T | WT–MCF-7; ZR75-1, BT-20 | Down | 0, 2, 4, 6, 8 | Sphere formation | [41] |
miR-7 | WT–MDA-MB-468 | – | – | 0, 2, 4, 6, 8 | Colony formation | [27] |
miR-16-5p | WT–MDA-MB-231 | WT–T47D | Down | 0, 2, 4, 6, 8, 10 | Cell viability (MTT) | [27] |
miR-22 | WT–MDA-MB-231 | WT–MCF-10A | Down | 0, 2, 4, 6, 8 6 | Colony formation DNA damage (γ-H2AX) | [40] |
miR-23b-3p | WT–MDA-MB-231 | WT–T47D | Down | 0, 2, 4, 6, 8, 10 | Cell viability (MTT) | [27] |
miR-27a | WT–MDA-MB-231, MDA-MB-435 | WT–MCF-10A | Up | 0, 8 0, 8 | Cell viability (CCK-8) Apoptosis (Caspase-3) | [28] |
miR-27a | WT–MDA-MB-231, MDA-MB-468 | – | – | 30, 50, 100 30, 50, 100 | Cell Viability (MTT) Apoptosis (Caspase-Glo3/7) | [70] |
miR-31 | WT–MDA-MB-231 | – | – | 5 | Cell Viability (CellTiter) | [62] |
miR-33a | WT–MDA-MB-231, SUM159 WT–SUM149 | WT – KPL4 WT – KPL4 | Up Down | 0, 2, 4, 6 | Colony formation | [41] |
miR-93-5p | W –MDA-MB-231, MDA-MB-468 | – | – | 0, 2 0, 2 0, 2 | Migration Cell viability (CCK-8) Apoptosis (Annexin V-FITC/PI) | [29] |
miR-93-5p | Tumor Xenograft model – MDA-MB-231 | – | – | FD -12 | Histopathological analysis | [55] |
miR-122 | RR–MDA-MB-231 RR–MDA-MB-231 | WT – MDA-MB-231 RR-MCF-7 | Up Up | 0, 2, 4, 6, 8 4 | Cell viability (MTT) Colony formation | [48] |
miR-129-5p | WT–MDA-MB-231 | WT–MCF-10A | Down | 0, 2, 4, 6, 8 0, 6 0, 6 | Colony formation Autophagy (GFP-LC3) Apoptosis (Caspase-3) | [42] |
miR-139-5p | WT–MDA-MB-157, MDA-MB-231, MDA-MB-453, MDA-MB-468, BT-20, HCC1937 | – | – | 0, 6 | Cell survival (MTS) | [67] |
miR-142-3p | WT–MDA-MB-468, HCC1806 | – | – | 0, 2, 4, 6 | Colony formation | [68] |
miR-144 | WT–MDA-MB-231, SKBR3 | – | – | 0, 30, 50, 100 0, 0.5, 2, 5 | Cell survival (WST-1) Apoptosis (Caspase-3/-7) | [71] |
miR-199a-5p | WT–MDA-MB-231 | Control group1 | Up | 0, 2, 4, 6 8 | Cell viability (CCK-8) Autophagy (GFP-LC3) | [49] |
miR-200c | WT – MDA-MB-231, BT549 | WT–MCF-10A | Down | 0, 2, 4, 6, 8 0, 2, 4, 6, 8 | Colony formation Cell proliferation | [30] |
miR-200c | WT – MDA-MB-468 | – | – | 0, 2, 4, 6, 8 0, 2 | Colony formation DNA damage (γ-H2AX) | [58] |
miR-200c | WT – MDA-MB-231, BT549 | WT – MCF-10A | Down | 0, 2, 4, 6, 8 0, 6 | Colony formation DNA damage (γ-H2AX) | [43] |
miR-205 | RR – SUM159 (SUM159-P2) WT – MDA-MB-231 Tumor Xenograft model – SUM159-P2 | WT – SUM159 (SUM159-P0) _ _ | Up _ _ | 0, 2, 4, 6 SD – 15 | Colony formation Tumor Volume | [50] |
miR-218 | WT – MDA-MB-468 | WT – MCF-7 | Down | 2 | Colony formation | [46] |
miR-302a | WT – MDA-MB-231, SKBR3 RR – MDA-MB-231 Tumor Xenograft model – RR – MDA-MB-231 | WT – MCF-7 WT – MDA-MB-231 _ | Up Up _ | 0, 2, 4, 6, 8, 10 SD – 5 | Colony formation Tumor Volume | [51] |
miR-454 | WT – MDA-MB-231, MDA-MB-468 | – | – | 0, 20, 40, 60 0, 5, 10, 20 | Cell proliferation Apoptosis assay (Caspase-Glo3/7) | [72] |
miR-634 | RR – MDA-MB-231 | WT – MDA-MB-231 | Up | 0, 2, 4, 6, 8 4 | Cell viability (MTT) Apoptosis (Annexin V-FITC/PI) | [52] |
miR-1290 | RR – MDA-MB-231 RR-Tissues samples | WT – MDA-MB-231 RS-Tissues samples | Down Down | 4 4 SD – 8 | Cell viability (MTT) Colony formation Tumor Volume | [45] |
miR-3188 | WT-MDA-MB-231, HCC1954 | – | – | 7.5 | Cell viability (MTT) | [63] |
lncRNAs | ||||||
LINC00511 | WT – MDA-MB-231, MDA-MB-436 | WT-MCF-7 | Up | 0, 2, 4, 6, 8, 10 0, 2, 4, 6, 8, 10 SD-10 | Cell viability (MTT) Apoptosis (Annexin V) Tumor Volume | [53] |
LINC00963 | WT – MDA-MB-231 | WT – MCF-12A | Up | 0, 2, 6, 10 0, 6 0, 6 | Colony formation ROS detection DNA damage (γ-H2AX) | [31] |
LINC00963 | RR – MDA-MB-231 WT – MDA-MB-231, SKBR3 | – | – | 4, 8 0, 2, 4, 8, 12 2, 8 | Colony formation Cell viability (CellTiter-Glo) Apoptosis | [56] |
AFAP1-AS1 | RR – MDA-MB-231 RR – Tissues samples Tumor Xenograft model – RR – MDA-MB-231 | WT – MDA-MB-231 RS – Tissues samples _ | Down Down _ | 0, 2, 4, 6, 8, 10 0, 6, 10 0, 6, 10 0, 6, 10 FD – 10 | Cell survival Apoptosis (Annexin V) Migration Invasion Tumor Volume | [32] |
CCAT1 | WT – MDA-MB-231 | Control group1 | _ | 0, 2, 4, 6, 8 6 | Colony formation Apoptosis (Caspase-3) | [61] |
DUXAP8 | WT – MDA-MB-231, BT-549 Tumor Xenograft model – MDA-MB-231 | WT – MCF-10A _ | Up _ | 0, 4, 8 0, 4, 8 SD – 8 | Cell viability (CCK-8) Apoptosis (Annexin V) Tumor Volume | [46] |
HOTAIR | WT-MDA-MB-231 | – | – | 0, 15, 20, 25 0, 6 | Cell viability (CCK-8) Colony formation | [33] |
NEAT1 | RR-MDA-MB-231 | WT-MDA-MB-231 | _ | 0, 2, 4 RR-Cell line | Colony formation Sphere formation | [57] |
PCAT6 | WT–MDA-MB-231, MDA-MB-468 RR–MDA-MB-231, RR- MDA-MB-468 | WT-MCF-10A _ | Up _ | 0, 2, 4, 6, 8 4 4 | Colony formation Cell viability (CCK-8) Apoptosis (Annexin V) | [47] |
circRNAs | ||||||
Circ_0008500 | WT–MDA-MB-468 Tumor Xenograft model – MDA-MB-468 | WT – MCF-10A _ | Up _ | 0, 4 0, 4 0, 4 FD–4 | Colony formation Apoptosis (Annexin V) Cell proliferation (EdU) Tumor formation | [34] |
CircNCOR1 | WT – MDA-MB-231, BT549 Tumor Xenograft model – MDA-MB-231 | _ _ | Up _ | 0, 2, 4, 6 0, 2, 4, 6 0, 6 FD—6 | Colony formation Apoptosis (Annexin V) Cell viability (CCK-8) Histopathological analysis | [54] |