Table 2 NcRNAs associated with radiosensitivity on TNBC-expression levels, mechanisms of action and biological impact
From: Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
ncRNAs | Manipulated expression level | Mechanism of Action | Biological Impact | Refs. |
|---|---|---|---|---|
MiRNAs | ||||
Let-7d | Overexpression | ↓Cyclin D1/Akt1/Wnt1 pathway (↓ CCND1) | ↓Self-renewal ability ↓ Stem cells population | [39] |
miR-7 | Overexpression | ↓EGFR pathway (↓ p-EGRF; ↓ p-Akt; ↓ p-ERK; ↓ p-STAT3) | ↓Cell survival | [69] |
miR-22 | Overexpression | ↓SIRT1 (SIRT1) | ↓Cell Survival ↓ DNA Repair | [40] |
miR-27a | Inhibition | ↑CDC27 (CDC27) ↑ Caspase-3 | ↓Cell Proliferation ↑ Apoptosis | [28] |
miR-31 | Overexpression | ↓PRKCE (PRKCE) ↓ BCL2 (BCL2) | ↓Cell Viability ↑ Apoptosis | [62] |
miR-33a | Inhibitor Overexpression | ↑ABCA1 (↑ HDL) | ↓Cell Survival | [41] |
miR-93-5p | Overexpression | – | ↓Migration ↓ Cell Viability ↑ Apoptosis | [29] |
miR-93-5p | Overexpression | ↓EphA4/NF-Kb pathway | ↓Tumor Formation ↑ Tumor Necrosis | [55] |
miR-122 | Inhibition | ↑ZNF304 (ZNF304) ↑ ZNF611 (ZNF611) ↓ RIPK1 (RIPK1) ↓ DUSP8 (DUSP8) | ↓Cell Proliferation ↓ Cell Survival | [48] |
miR-129-5p | Overexpression | ↓HMGB1 (HMGB1) ↓ LC3II ↓ p62 ↑ Caspase-3 ↑ c-PARP | ↓Cell Survival ↓ Autophagy ↑ Apoptosis | [42] |
miR-139-5p | Overexpression | ↓DDR pathways (Mutations: TP53; CDKN2A; PTEN; ATM; EP300; BRAF; KRAS; BRCA1; RB1; SCAI) | ↓Cell Survival ↓ DNA repair | [67] |
miR-142-3p | Overexpression | ↓BRCA1 (BRCA1) ↓ BRCA2 (BRCA2) ↓ BOD1 (BOD1) ↓ KLF4 (KLF4) | ↓Cell Survival ↓ DNA repair ↓ Stem cells population | [68] |
miR-199a-5p | Overexpression | ↑LC3-I ↑ LC3-II ↑ DRAM1 ↑ Beclin1 | ↓Cell Viability ↑ Autophagy | [49] |
miR-200c | Overexpression | ↓UBQLN1 (UBQLN1) ↓ LC3II ↑ p62 ↑ Caspase-3 ↑ c-PARP | ↓Cell Survival ↓ Autophagy ↑ Apoptosis | [30] |
miR-200c | Overexpression | ↓NHEJ pathway (↓ p-DNA-PKs) | ↑Cell Survival ↑ DNA Repair | [58] |
miR-200c | Overexpression | ↓LINC02582 (↓ USP7 (USP7); ↓ CHK1 (CHK1)) | ↑Cell Survival ↑ DNA Repair | [43] |
miR-205 | Overexpression | ↓HR pathway (↓ ATM; ↓ ZEB1; ↓ UBE2N (UBC13)) | ↑Cell Survival ↓ Tumor Growth | [50] |
miR-218 | Overexpression | ↓EGFR (EGFR) (↓ p44/42 MAPK signaling) | ↓Cell Survival | [44] |
miR-302a | Overexpression | ↓AKT1 (AKT1) ↓ RAD52 (RAD52) | ↓Cell Survival ↓ Tumor Growth | [51] |
miR-634 | Overexpression | ↑Caspase-3 ↑ PARP | ↓Cell Viability ↑ Apoptosis | [52] |
miR-3188 | Overexpression | ↓mTORC2 pathway (↓ Rictor; ↓ p-AKT, ↑ PARP) | ↓Cell Viability | [63] |
LncRNAs | ||||
LINC00511 | Inhibition | ↑STXBP4 (STXBP4) (Mediated by ↓ miR-185) | ↓Cell Viability ↓ Apoptosis ↓ Tumor Growth | [53] |
LINC00963 | Inhibition | – | ↓Cell Survival ↓ DNA Repair ↓ ROS | [31] |
AFAP1-AS1 | Inhibition | ↑ p-GSK3β (↑ β-catenin destruction complex) | ↓Cell Survival ↓ Migration ↓ Invasion ↓ Apoptosis ↓ Tumor Growth | [32] |
CCAT1 | Inhibition | ↑Caspase-3 (Mediated by ↑ miR-148b) | ↓Cell Survival ↓ Apoptosis | [61] |
DUXAP8 | Inhibition | ↑E-cadherin ↑ RHOB | ↓Cell Survival ↑ Apoptosis ↓ Tumor Volume | [46] |
NEAT1 | Inhibition | ↓ BMI1 ↓OCT4 ↓SOX2 | ↓Cell Survival ↓ Stem cells population | [57] |
PCAT6 | Inhibition | ↓TPD52 | ↓Cell Viability ↓ Cell Proliferation ↑ Apoptosis | [47] |
CircRNAs | ||||
Circ_0008500 | Inhibition | ↑BAX; ↓ BCL2 (Mediated by ↓ miR-758-3p/PFN2 axis) | ↓Cell Proliferation ↑ Apoptosis ↓ Tumor Growth | [34] |