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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages

Fig. 4

Secretome analysis of DPSC-CM-produced in normoxya and hypoxia. We evaluated the secretome of DPSC-CM Normox and DPSC-CM Hypox by antibody-membrane arrays. A Schematic representation for the generation of the DPSC-CMs in normoxia and hypoxia; B Representative imagens showing the morphology of DPSCs maintained in normoxia nd hypoxia a 48 and 72 h; C qPCR showing the expression levels of hypoxia-inducible target genes (IL-6, VEGF-A,SDF1, CXCL8, MCP1, MMP2), on DPSCs cultured in normoxia or hypoxia, for 48–72–96 h; D western blot showing the activation of STAT3 pathway, as readout on an hypoxia-mediated signalling, in DPSCs cultured in normoxia or hypoxia, for 48–72–96 h; E analysis of the frequency of up, down, and not-regulated factors within the overall arrays and overall heatmap showing the modulation of factors present in C6 and C7 membrane-arrays

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Journal of Biomedical Science

ISSN: 1423-0127