Fig. 5

OGG1’s role in transcriptional activation of inflammatory genes. Transient accumulation of 8-oxoGua and OGG1 in GC-rich regulatory regions of pro-inflammatory genes in response to oxidative stress facilitates recruitment of sequence-specific transcription factors such as NF-κB, Sp1 along with chromatin modifiers and phosphorylated RNA polymerase II. In addition, OGG1 interacts with mitogen and stress-activated kinase 1 (MSK1), which promotes phosphorylation of RelA/p65 at Ser276, thereby increasing expression of ROS-responsive cytokine/chemokine genes