Fig. 4

The tumor characteristics and prognosis of patients with HBV-TERT(+) HCCs tend to be mitigated by HCV superinfection. A, B Comparison of RFS (A) and OS (B) between int(+) HBV-HCCs (green line), int(–) HCV-HCCs (magenta line), int(+) HBCV-HCCs (orange line), and int(–) HBCV-HCCs (gray line) patients by Kaplan‒Meier analysis. C, D Comparison of RFS (C) and OS (D) of HBV-TERT (+) HBCV-HCCs (red line) and HBV-TERT (+) HBV-HCCs (blue line) patients by Kaplan‒Meier analysis. E, F GSEA plots of gene sets related to (E) CTNNB1 downstream signaling and (F) cell stemness between HBV-TERT(+) HBCV-HCCs (n = 3) and HBV-TERT(+) HBV-HCCs (N = 15).