miR-200c inhibition and catalase accelerate diabetic wound healing

Table 1 Nonlinear mixed-effects models

	Estimate	Std. Error	t value	p.val
xmid	3.98	0.39	10.08	< 0.0001***
xmid3	4.75	0.68	7.01	< 0.0001***
xmid4	1.44	0.70	2.10	0.0384*
scal	− 1.83	0.13	− 13.73	< 0.0001***
scal2	0.81	0.27	3.03	0.0024**

xmid comparison among the groups
	est.diff	se.diff	z.diff	p.val	adjust.p (FDR)
3–1	4.75	0.68	7.01	2.37 e-12	< 0.0001 ***	(= 3–2)
4–1	1.44	0.70	2.10	3.84 e-02	0.0384 *	(= 4–2)
4–3	− 3.31	0.80	− 4.15	3.29 e-05	< 0.0001 ***	(= 3–2)

xmid3 gives the estimate of the difference in the x-midpoint between anti-miR-scramble (group 3) and groups 1 and 2 (anti-miR-200c w/o CAT and anti-miR-200c + CAT) and xmid 4 gives the estimate of the difference in the x-midpoint between anti-miR-scramble + with CAT (group 4) and groups 1 and 2. Scal2 estimates the difference in the scale parameter between group 2 and groups 1, 3, and 4. anti-miR-200c w/o CAT = 1; anti-miR-200c with CAT = 2; anti-miR-scramble w/o CAT = 3; anti-miR-scramble with CAT = 4

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