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Table 2 The dissociation constant values (Kd) obtained from the MST analysis for PGN, LPS, individual excipients (HA, Lys and HA-Lys conjugate), VCM-HNLCs and non-hybrid NLCs components binding to TLR2 and TLR4, respectively

From: Multifunctional hyaluronic acid-based biomimetic/pH-responsive hybrid nanostructured lipid carriers for treating bacterial sepsis

Test ligand

Kd (µM)

 

TLR2

TLR4

PGN

23.945 ± 0.880

LPS

38.145 ± 1.440

HA

0.8237 ± 0.414

0.045 ± 0.750

Lys

2.785 ± 0.740

43.530 ± 2.352

HA-Lys

0.0207 ± 0.848

0.187 ± 0.733

VCM-HNLCs

4.551 ± 0.485

2.443 ± 2.168

Non-hybrid NLCs components

202.1 ± 1.360

52.289 ± 2.206

  1. Data are presented as mean ± SD (n = 3)