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Table 4 The minimum inhibitory concentration (MIC) values (μg/mL) for S. aureus and MRSA at pH 7.4 and pH 6.0, respectively, for bare VCM, blank HNLCs and VCM-HNLCs

From: Multifunctional hyaluronic acid-based biomimetic/pH-responsive hybrid nanostructured lipid carriers for treating bacterial sepsis

S. aureus (μg/mL)

Time (h)

24

48

72

24

48

72

pH 7.4

pH 6.0

Bare VCM

3.90

3.90

7.80

3.90

7.80

7.80

Blank HNLCs

16.11

16.11

16.11

16.11

16.11

16.11

VCM-HNLCs

1.95

1.95

1.95

0.98

0.98

0.98

MRSA (μg/mL)

Time (h)

24

48

72

24

48

72

pH 7.4

pH 6.0

Bare VCM

7.80

7.80

15.62

7.80

15.62

15.62

Blank HNLCs

32.22

32.22

32.22

32.22

32.22

32.22

VCM-HNLCs

3.90

3.90

3.90

1.95

1.95

1.95

  1. The test was done in triplicate (n = 3)
  2. VCM: Vancomycin free base; HNLCs: hybrid nanostructured lipid carriers