Fig. 1

The abundance of peroxisomes in the sciatic nerves is decreased in diabetic mice. A A schematic diagram showing the treatments of the mice. B Blood glucose monitoring. Data is shown as means ± SEM with two-way ANOVA with Sidak’s tests (n = 8 per group). **p < 0.01. C Immunoblotting with antibodies against peroxisomes-related proteins in sciatic nerves from control and STZ-induced diabetic mice (n = 3 per group). Actin was used as a loading control. D Quantification of peroxisomes-related proteins. Data is shown as means ± SEM with Unpaired t test. *p < 0.05. E Representative immunofluorescence staining for PMP70 (green) on sciatic nerves sections from control and STZ-induced diabetic mice. Right: enlarged image of area indicated by dashed box. POs: peroxisomes. F Quantification of peroxisomes (POs) number. Data is shown as means ± SD with Unpaired t test (n = 26 cells). ***p < 0.001