Fig. 8
From: PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy
Schematic diagram showing the peroxisomal dysfunction in DN. At the animal level, a decrease in peroxisomal abundance was observed in the sciatic nerves of diabetic mice; Fenofibrate treatment rescued peroxisomal dysfunction in these mice. At the cellular level, PA treatment inhibits peroxisomal biogenesis; Mechanistically, PA treatment led to the palmitoylation of PEX11B, thereby disrupting its self-interaction and inhibiting peroxisomal elongation. Additionally, Fenofibrate treatment could restore peroxisomal abundance. MR analysis indicated a significant causal influence of DN on MS