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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice

Fig. 4

AT-Exos from different depots participate in inflammation and metabolic homeostasis of adipocytes. A-C Top GO terms of the differentially expressed genes of 3T3L1 treated with vWAT-Exos (panel a), iWAT-Exos (panel b) and BAT-Exos (panel c) derived from HFD-fed and LFD-fed mice based on RNA-seq analysis. Red box and blue box represent upregulated and downregulated GO terms, respectively. D-F Normalized expression of inflammation-related genes in 3T3L1 treated with vWAT-Exos (panel d), iWAT-Exos (panel e) and BAT-Exos (panel f) derived from HFD-fed and LFD-fed mice. n = 5 per group. G-I ELISA analysis of IL-1β (panel g), IL-6 (panel h) and TNF-ɑ (panel i) concentration of 3T3L1 supernatant treated with AT-Exos derived from HFD-fed and LFD-fed mice. n = 5 per group. J-L Normalized expression of lipid metabolism genes in 3T3L1 treated with vWAT-Exos (panel j), iWAT-Exos (panel k) and BAT-Exos (panel l) derived from HFD-fed and LFD-fed mice. n = 5 per group. All data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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Journal of Biomedical Science

ISSN: 1423-0127