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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Lacking ASIC1a in ASIC4-positive amygdala/bed nucleus of the stria terminalis (BNST) neurons reduces anxiety and innate fear in mice

Fig. 7

Restoring ASIC4 expression in the BNST rescued anxiety phenotypes of Asic4 knockout (Asic4−/−) mice. a Representative image of Asic4−/− BNST injected with AAV-DIO-mCherry. b Western blot analysis of ASIC4 protein in the BNST of Asic4+/+ mice and Asic4−/− mice transfected with AAV-DIO-ASIC4WT(or Mutants); actin was a loading control. c Effect of restoring BNST ASIC4 (or its mutants) on Asic4−/− mouse behaviors in open-field test, (d) EPM test, and (e) TMT-evoked freezing test (N = 10 mice in each group). **p < 0.01, *** p < 0.001 vs. mCherry. Data are mean ± SEM

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Journal of Biomedical Science

ISSN: 1423-0127