Table 2 Comparison of mutated Spike peptide-HLA binding affinities between SARS-CoV-2 variants in different populations
Binding affinity | Taiwanese | British | Russian | ||||||
|---|---|---|---|---|---|---|---|---|---|
EG.5 | XBB.1.16 | p-valuea | EG.5 | XBB.1.16 | p-valuea | EG.5 | XBB.1.16 | p-valuea | |
HLA class I | |||||||||
 Strong, n (%) | 13 (11.7%) | 16 (11.9%) | 0.997 | 18 (12.7%) | 15 (9.1%) | 0.441 | 16 (12.1%) | 14 (9%) | 0.444 |
 Medium, n (%) | 66 (59.5%) | 79 (59%) | 72 (50.7%) | 80 (48.5%) |  | 75 (56.8%) | 83 (53.5%) | ||
 Weak/no, n (%) | 32 (28.8%) | 39 (29.1%) | 52 (36.6%) | 70 (42.4%) |  | 41 (31.1%) | 58 (37.4%) | ||
HLA class II | |||||||||
 Strong, n (%) | 140 (13.4%) | 118 (10.5%) | 0.047* | 123 (6.9%) | 136 (6.6%) | 0.656 | 211 (15.4%) | 89 (5%) | 1.374 × 10–21* |
 Medium, n (%) | 670 (63.9%) | 769 (68.5%) | 1188 (66.8%) | 1413 (68.2%) |  | 883 (64.3%) | 1292 (72.9%) | ||
 Weak/no, n (%) | 238 (22.7%) | 236 (21%) | 468 (26.3%) | 524 (25.3%) |  | 280 (20.4%) | 391 (22.1%) | ||