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  1. Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of effective targeted therapy. Although the study of interplay between cancer cells with their microenvironme...

    Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:109
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2023 30:54

  2. The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics. Therefore, it would be of gr...

    Authors: Shih-Han Ko, Wan-Yu Chen, Shih-Chieh Su, Hsiu-Ting Lin, Feng-Yi Ke, Kang-Hao Liang, Fu-Fei Hsu, Monika Kumari, Chi-Yu Fu and Han-Chung Wu
    Citation: Journal of Biomedical Science 2022 29:108
    Content type: Research Published on:

  3. Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcr...

    Authors: Anna Niewiadomska-Cimicka, Antoine Hache, Stéphanie Le Gras, Céline Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. Roux, Nadia Messaddeq, Emmanuelle Clérin, Thierry Léveillard and Yvon Trottier
    Citation: Journal of Biomedical Science 2022 29:107
    Content type: Research Published on:

  4. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcri...

    Authors: Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L. Ryu, Neil W. Kowall, Hoon Ryu and Junghee Lee
    Citation: Journal of Biomedical Science 2022 29:106
    Content type: Research Published on:

  5. In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathways governing angiogenesis. PLCβ1 is inactivated by complexing with an intracellular protein call...

    Authors: Sheng-Hung Wang, Jing-Yan Cheng, Hsiu-Hui Tsai, Tzu-Chi Lo, Jung-Tung Hung, Chun-Cheng Lin, Chien-Wei Lee, Yi-Hsuan Ho, Huan-Hsien Kuo, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2022 29:105
    Content type: Research Published on:

  6. Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (ln...

    Authors: Che-Yuan Hu, Bing-Hua Su, Ya-Che Lee, Chung-Teng Wang, Mei-Lin Yang, Wan-Ting Shen, Jing-Ting Fu, Shih-Yao Chen, Wei-Yun Huang, Chien-Hui Ou, Yuh-Shyan Tsai, Feng-Chih Kuo, Ai-Li Shiau, Gia-Shing Shieh and Chao-Liang Wu
    Citation: Journal of Biomedical Science 2022 29:104
    Content type: Research Published on:

  7. Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-depleted conditions which leads to suppression of lung cancer cell metastasis has been report...

    Authors: Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang, Yeh-Shiu Chu, Chi-Ying Huang, Kai-Ying Lan, Hsiao-Sheng Liu and Sheng-Hui Lan
    Citation: Journal of Biomedical Science 2022 29:103
    Content type: Research Published on:

  8. yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) genes to influence bacteria–host interactions...

    Authors: Hung-Hao Fan, Shiuh-Bin Fang, Yu-Chu Chang, Sheng-Tung Huang, Chih-Hung Huang, Pei-Ru Chang, Wei-Chiao Chang, Lauderdale Tsai-Ling Yang, Pei-Chun Lin and Hung-Yen Cheng
    Citation: Journal of Biomedical Science 2022 29:102
    Content type: Research Published on:

  9. Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear. Decidualization is critical for the establishment and maintenance of norma...

    Authors: Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang and Meirong Du
    Citation: Journal of Biomedical Science 2022 29:101
    Content type: Research Published on:

  10. Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endo...

    Authors: Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O’Malley and Sang Jun Han
    Citation: Journal of Biomedical Science 2022 29:100
    Content type: Research Published on:

  11. Sorafenib (SOR) is the first line treatment for advanced hepatocellular carcinoma (HCC), but resistance develops frequently. Tumor-associated macrophages (TAMs) have been reported to affect the progression of ...

    Authors: Hao-Chen Wang, Lin-Ya Haung, Chih-Jung Wang, Ying-Jui Chao, Ya-Chin Hou, Chia-Jui Yen and Yan-Shen Shan
    Citation: Journal of Biomedical Science 2022 29:99
    Content type: Research Published on:

  12. Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal ...

    Authors: Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai and Hua-Lin Wu
    Citation: Journal of Biomedical Science 2022 29:98
    Content type: Research Published on:

  13. The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during ch...

    Authors: Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee and Simanti Datta
    Citation: Journal of Biomedical Science 2022 29:97
    Content type: Research Published on:

  14. In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and proteomic levels and have furthered our understanding of th...

    Authors: Wan-Chen Hsieh, Bugi Ratno Budiarto, Yi-Fu Wang, Chih-Yu Lin, Mao-Chun Gwo, Dorothy Kazuno So, Yi-Shiuan Tzeng and Shih-Yu Chen
    Citation: Journal of Biomedical Science 2022 29:96
    Content type: Review Published on:

  15. Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial...

    Authors: Fara Silvia Yuliani, Jing-Yun Chen, Wen-Hao Cheng, Heng-Ching Wen, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2022 29:95
    Content type: Research Published on:

  16. Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are ...

    Authors: Makoto Kurano, Daisuke Jubishi, Koh Okamoto, Hideki Hashimoto, Eri Sakai, Yoshifumi Morita, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya and Yutaka Yatomi
    Citation: Journal of Biomedical Science 2022 29:94
    Content type: Research Published on:

  18. Phosphatase and tensin homolog (PTEN) is a tumor suppressor. Low PTEN expression has been observed in pancreatic neuroendocrine tumors (pNETs) and is associated with increased liver metastasis and poor surviva...

    Authors: Tsung-Ming Chang, Pei-Yi Chu, Hui-You Lin, Kuo-Wei Huang, Wen-Chun Hung, Yan-Shen Shan, Li-Tzong Chen and Hui-Jen Tsai
    Citation: Journal of Biomedical Science 2022 29:92
    Content type: Research Published on:

  20. Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer-associated death worldwide with a dismal overall 5-year survival rate of less than 20%. The standard first-line therapy for advanc...

    Authors: Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2022 29:90
    Content type: Research Published on:

  21. Understanding the mechanism of antimicrobial action is critical for improving antibiotic therapy. For the first time, we integrated correlative metabolomics and transcriptomics of Pseudomonas aeruginosa to elucid...

    Authors: Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T. Tsuji, Darren J. Creek, Tony Velkov and Jian Li
    Citation: Journal of Biomedical Science 2022 29:89
    Content type: Research Published on:

  22. Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis have been reported to be enriched in colorectal cancer (CRC) in multiple studies. ...

    Authors: Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang and Ling-Hui Li
    Citation: Journal of Biomedical Science 2022 29:88
    Content type: Research Published on:

  23. Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably severe pulmonary symptoms, cardi...

    Authors: Alain C. Borczuk and Rhonda K. Yantiss
    Citation: Journal of Biomedical Science 2022 29:87
    Content type: Review Published on:

  24. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. P...

    Authors: Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2022 29:86
    Content type: Review Published on:

  25. Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observe...

    Authors: Benjamin Chun-Kit Tong, Alexis Shiying Huang, Aston Jiaxi Wu, Ashok Iyaswamy, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Min Li and King-Ho Cheung
    Citation: Journal of Biomedical Science 2022 29:85
    Content type: Research Published on:

  28. Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid development and deployment of effective COVID-19 vaccines have suc...

    Authors: Wei-Yu Chi, Yen-Der Li, Hsin-Che Huang, Timothy En Haw Chan, Sih-Yao Chow, Jun-Han Su, Louise Ferrall, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2022 29:82
    Content type: Review Published on:

  29. Patients with colon adenocarcinoma (COAD) exhibit significant heterogeneity in overall survival. The current tumor-node-metastasis staging system is insufficient to provide a precise prediction for prognosis. ...

    Authors: Jing Lu, Francesco Annunziata, Dovydas Sirvinskas, Omid Omrani, Huahui Li, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Lisa Adam and Francesco Neri
    Citation: Journal of Biomedical Science 2022 29:81
    Content type: Research Published on:

  30. Human Papillomavirus type 18 (HPV18) is a high-risk HPV that is commonly associated with cervical cancer. HPV18 oncogenes E6 and E7 are associated with the malignant transformation of cells, thus the identific...

    Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung and T.-C. Wu
    Citation: Journal of Biomedical Science 2022 29:80
    Content type: Research Published on:

  32. Escherichia coli sequence type (ST)131 is an important urinary tract pathogen, and is responsible for considerable healthcare-associated problems and costs worldwide. A better understanding of the factors that co...

    Authors: Timothy Kudinha and Fanrong Kong
    Citation: Journal of Biomedical Science 2022 29:78
    Content type: Research Published on:

  33. Living organisms are continuously exposed to multiple internal and external stimuli which may influence their emotional, psychological, and physical behaviors. Stress can modify brain structures, reduces funct...

    Authors: Ola Salhab, Luna Khayat and Nada Alaaeddine
    Citation: Journal of Biomedical Science 2022 29:77
    Content type: Review Published on:

  34. Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinas...

    Authors: Pei-Jane Tsai, Yi-Hsin Lai, Rajesh Kumar Manne, Yau-Sheng Tsai, Dos Sarbassov and Hui-Kuan Lin
    Citation: Journal of Biomedical Science 2022 29:76
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2023 30:7

  35. The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic a...

    Authors: Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng and Jiu-Yao Wang
    Citation: Journal of Biomedical Science 2022 29:75
    Content type: Research Published on:

  36. The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidati...

    Authors: Cheng-Liang Kuo, Ananth Ponneri Babuharisankar, Ying-Chen Lin, Hui-Wen Lien, Yu Kang Lo, Han-Yu Chou, Vidhya Tangeda, Li-Chun Cheng, An Ning Cheng and Alan Yueh-Luen Lee
    Citation: Journal of Biomedical Science 2022 29:74
    Content type: Review Published on:

  37. Mesenchymal stem cells (MSCs) exhibit two bidirectional immunomodulatory abilities: proinflammatory and anti-inflammatory regulatory effects. Long noncoding RNAs (lncRNAs) have important functions in the immun...

    Authors: Jiajie Lin, Zhongyu Xie, Zhaoqiang Zhang, Ming Li, Guiwen Ye, Wenhui Yu, Jinteng Li, Feng Ye, Zepeng Su, Yunshu Che, Peitao Xu, Chenying Zeng, Peng Wang, Yanfeng Wu and Huiyong Shen
    Citation: Journal of Biomedical Science 2022 29:73
    Content type: Research Published on:

  39. Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific chromatin locations by orchestrating and modifying histone complexes...

    Authors: Jayaprakash Mandal, Prativa Mandal, Tian-Li Wang and Ie-Ming Shih
    Citation: Journal of Biomedical Science 2022 29:71
    Content type: Review Published on:

  40. Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple-negative breast cancers (TNBCs) and improving immune su...

    Authors: Li-Mei Chen, Pao-Pao Yang, Aushia Tanzih Al Haq, Pai-An Hwang, You-Chen Lai, Yueh-Shan Weng, Michelle Audrey Chen and Hsin-Ling Hsu
    Citation: Journal of Biomedical Science 2022 29:70
    Content type: Research Published on:

  41. The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-co...

    Authors: Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-yang Ding and Bixiang Zhang
    Citation: Journal of Biomedical Science 2022 29:69
    Content type: Review Published on:

  42. The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed...

    Authors: Monika Kumari, Ruei-Min Lu, Mu-Chun Li, Jhih-Liang Huang, Fu-Fei Hsu, Shih-Han Ko, Feng-Yi Ke, Shih-Chieh Su, Kang-Hao Liang, Joyce Pei-Yi Yuan, Hsiao-Ling Chiang, Cheng-Pu Sun, I.-Jung Lee, Wen-Shan Li, Hsing-Pang Hsieh, Mi-Hua Tao…
    Citation: Journal of Biomedical Science 2022 29:68
    Content type: Review Published on:

  45. Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit, vaccination stands as a practical ...

    Authors: Kunal Nepali, Ram Sharma, Sachin Sharma, Amandeep Thakur and Jing-Ping Liou
    Citation: Journal of Biomedical Science 2022 29:65
    Content type: Review Published on:

  46. O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible modification is catalysed by a uniq...

    Authors: Tarik Issad, Hasanain Al-Mukh, Abdelouhab Bouaboud and Patrick Pagesy
    Citation: Journal of Biomedical Science 2022 29:64
    Content type: Review Published on:

  47. Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldwide. Fibrosis is defined by excessive extracellular matrix deposition at fibrotic foci in the organ...

    Authors: Chen-Ting Hung, Yi-Wei Tsai, Yu-Shuo Wu, Chih-Fan Yeh and Kai-Chien Yang
    Citation: Journal of Biomedical Science 2022 29:63
    Content type: Review Published on:

  48. Increasing evidences have suggested an important role of microRNAs (miRNAs) in regulating cell death processes including NETosis and apoptosis. Dysregulated expression of miRNAs and increased formation of neut...

    Authors: Yu-Tung Hsieh, Yu-Chi Chou, Pin-Yu Kuo, Hung-Wen Tsai, Yi-Ting Yen, Ai-Li Shiau and Chrong-Reen Wang
    Citation: Journal of Biomedical Science 2022 29:62
    Content type: Research Published on:

  49. CYP11A1 is a protein located in the inner membrane of mitochondria catalyzing the first step of steroid synthesis. As a marker gene for steroid-producing cells, the abundance of CYP11A1 characterizes the exten...

    Authors: Karen G. Rosal, Wei-Yi Chen and Bon-chu Chung
    Citation: Journal of Biomedical Science 2022 29:61
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127